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2184: Symmetric Hexamer Design with AlphaFold Predictions Status: Active |
| Name: | 2184: Symmetric Hexamer Design with AlphaFold Predictions |
|---|---|
| Status: | Active |
| Created: | 08/10/2022 |
| Points: | 100 |
| Expires: | 08/17/2022 – 23:00 |
| Difficulty: | Intermediate |
| Description: | Design a symmetric protein hexamer, with 6 similar chains of 80 residues every! This puzzle permits AlphaFold predictions for the monomer subunit of your design, so you may add your answer for AlphaFold utilizing the AlphaFold prediction device. AlphaFold will predict the construction of your monomer subunit solely (i.e. within the unbound state, within the absence of different symmetric copies). If you load this prediction, then Foldit will try to align the prediction along with your answer. If you proceed working off of the AlphaFold prediction, it’s possible you’ll have to make changes on the interface the place the monomer subunit interacts with symmetric copies.
This puzzle features a Secondary Structure Objective, so not more than 50% of your design can type helices. The H-bond Network Objective encourages gamers to construct buried, glad H-bond networks on the interface between symmetric chains. H-bond networks are an effective way to introduce polar residues on the interface, nevertheless it’s essential that all the bondable atoms make hydrogen bonds! We’ve additionally adjusted the H-bond Network Objective in order that poor-scoring H-bonds could not contribute to networks; poor-scoring H-bonds might be displayed in pink. This puzzle makes use of the Buried Unsats Objective, with a big penalty for buried polar atoms that may’t make H-bonds. In this puzzle, there are not any limits on the Complex Core, however we have included the Complex Core goal so gamers can see the core residues that may be included into H-bond Networks. |
| Categories: | Design, Overall, Symmetry |
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