This tough Connect Wall resolves like so:

Group 1: Band names lacking numbers

One Direction
U2
Jackson 5
Sum 41

Group 2: Crayola colors

Beaver
Fuzzy Wuzzy
Mountain Meadow
Outer Space

Group 3: Can take away the chemical image of a noble fuel to type one other phrase

C[He]at = CAT with out He (Helium)
[Ne]gate = GATE with out Ne (Neon)
Ste[Rn]al = STEAL with out Rn (Radon)
Wa[Xe]r = WAR with out Xe (Xenon)

([Kr]unwell was a merciless crimson herring on this class!)

Group 4: First and final letters are consecutive within the English alphabet

CoD
ElF
OkayrilL
StraiT

The phrase that hyperlinks all 4 classes is:

MAROON
Maroon 5
The color ‘maroon’
M[Ar]oon = MOON with out Ar (Argon)
MarooN

This additionally matches with the title, since:

to ‘maroon’ any individual is to abandon them!