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2186: CD47 Binder Design: Round 13

Status: Active

Name: 2186: CD47 Binder Design: Round 13
Status: Active
Created: 08/12/2022
Points: 100
Expires: 08/19/2022 – 23:00
Difficulty: Intermediate
Description: Design a protein that may bind to CD47! This puzzle has a lowered BUNS penalty in order that gamers can deal with different Objectives–but do not forget about BUNS utterly! AlphaFold predictions can be found in your designed binder. Once you’ve got designed a binder for the goal, add your answer for AlphaFold utilizing the AlphaFold prediction software. AlphaFold will predict the construction of your binder chain solely (i.e. within the unbound state, within the absence of the goal). If you load this prediction, then Foldit will try to align the prediction together with your answer (i.e. within the sure state, making an interface with the goal). If you proceed working off of the AlphaFold prediction, it’s possible you’ll must make changes on the interface the place the binder interacts with the goal.

CD47 is a protein displayed on floor of human cells. Normally, CD47 is offered to the immune system as a “pleasant” sign, and might stop an over-zealous immune system from attacking wholesome human tissue. However, some forms of most cancers will over-produce CD47 as a option to evade the immune system, camouflaging a tumor as “pleasant” human tissue. A protein that binds to CD47 may be helpful for treating these kinds of most cancers. We’d wish to design a protein binder that may block CD47 recognition by the immune system, and permit immune cells to assault tumors within the physique.

In this puzzle, we have offered a piece of the CD47 goal that’s acknowledged by the immune system. The spine and a lot of the sidechains are frozen, besides on the binding website, the place versatile sidechains are proven in coloration. Players can design a brand new protein that may bind to those sidechains and block CD47 recognition. In order to bind the goal, designs might want to make numerous hydrophobic contacts and fulfill any polar atoms which might be buried on the interface. But designs may also must have numerous secondary construction (helices or sheets) and a big core, in order that they fold up accurately! See the puzzle feedback for Objective particulars.

Categories: Design, Overall

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