The monkeypox H3 protein is displayed on the floor of the virus. The full position of H3 continues to be unclear, but it surely appears to be concerned within the recognition of human cells. A binder for H3 might be helpful for detecting monkeypox, and may even assist to dam an infection. Scientists have but to resolve the construction of the monkeypox H3 protein, though we do have a crystal construction of a associated protein from Vaccinia virus. The construction of the goal on this puzzle comes from an AlphaFold prediction of monkeypox H3.

In this puzzle, we have offered a portion of the H3 goal with a number of uncovered hydrophobic residues, which we expect might be good for binding. The spine and a lot of the sidechains are frozen, besides on the binding website, the place versatile sidechains are proven in colour. Players can design a brand new protein that may bind to those sidechains on the goal. In order to bind the goal, designs might want to make a lot of hydrophobic contacts and fulfill any polar atoms which might be buried on the interface. But designs may even have to have a lot of secondary construction (helices or sheets) and a big core, in order that they fold up appropriately! See the puzzle feedback for Objective particulars.