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2193: Symmetric Pentamer Design with AlphaFold Predictions


2193: Symmetric Pentamer Design with AlphaFold Predictions

Status: Active

Name: 2193: Symmetric Pentamer Design with AlphaFold Predictions
Status: Active
Created: 08/31/2022
Points: 100
Expires: 09/07/2022 – 23:00
Difficulty: Intermediate
Description: Design a symmetric protein pentamer, with 5 an identical chains of 80 residues every! This puzzle allows AlphaFold predictions for the monomer subunit of your design, so you may add your resolution for AlphaFold utilizing the AlphaFold prediction software. AlphaFold will predict the construction of your monomer subunit solely (i.e. within the unbound state, within the absence of different symmetric copies). If you load this prediction, then Foldit will try to align the prediction together with your resolution. If you proceed working off of the AlphaFold prediction, it’s possible you’ll have to make changes on the interface the place the monomer subunit interacts with symmetric copies.

This puzzle features a Secondary Structure Objective, so not more than 50% of your design can type helices. The H-bond Network Objective encourages gamers to construct buried, glad H-bond networks on the interface between symmetric chains. H-bond networks are an effective way to introduce polar residues on the interface, nevertheless it’s essential that the entire bondable atoms make hydrogen bonds! We’ve additionally adjusted the H-bond Network Objective in order that poor-scoring H-bonds could not contribute to networks; poor-scoring H-bonds shall be displayed in crimson. This puzzle makes use of the Buried Unsats Objective, with a big penalty for buried polar atoms that may’t make H-bonds. In this puzzle, there are not any limits on the Complex Core, however we have included the Complex Core goal so gamers can see the core residues that may be integrated into H-bond Networks.

Categories: Design, Overall, Symmetry

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